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2007 Duensing A, Duensing S. Centrosomes, polyploidy and cancer. In Poon R (Ed.), Polyploidization and Cancer, 2008 Landes Bioscience. (in press). Duensing A, Chin A, Wang L, Kuan SF, Duensing S. Analysis of centrosome overduplication in correlation to cell division errors in high-risk human papillomavirus (HPV)-associated anal neoplasms. Virology 2007; advanced online publication November 22, 2007. PubMed Spardy N, Duensing A, Charles D, Haines N, Nakahara T, Lambert PF, Duensing S. Human papillomavirus type 16 E7 activates the Fanconi Anemia (FA) pathway and causes accelerated chromosomal instability in FA cells. J. Virol. 2007; advanced online publication September 27, 2007. PubMed Duensing A and Duensing S. Centrosome-mediated chromosomal instability and steroid hormones as co-factors in human papillomavirus-associated cervical carcinogenesis: Small viruses help to answer big questions. In: Li JJ, Li SA, Mohla S, Rochefort H, Maudelone T (Eds.) Hormonal Carcinogenesis V, Springer, New York, USA, pp. 119-127 (2007) (in press). Duensing S, Moore PS, Parsonnet J. Infectious agents and cancer. In: Alison MR (Ed.) The Cancer Handbook, 2nd Edition, Wiley & Sons, Chichester, England, UK, pp. 372-387 (2007). Bauer S, Duensing A, Demetri GD, Fletcher JA. KIT oncogenic signaling mechanisms in imatinib-resistant gastrointestinal stromal tumor: PI3-Kinase/AKT is a crucial survival pathway. Oncogene 2007; advanced online publication June 4, 2007. PubMed Duensing A, Liu Y, Perdreau SA, Kleylein-Sohn J, Nigg EA, Duensing S. Centriole overduplication through the concurrent formation of multiple daughter centrioles at single maternal templates. Oncogene 2007; 26:6280-6288. PubMed Liu Y, Tseng M, Perdreau SA, Rossi F, Antonescu C, Besmer P, Fletcher JA, Duensing S, Duensing A. Histone H2AX is a mediator of gastrointestinal stromal tumor (GIST) cell apoptosis following treatment with imatinib mesylate. Cancer Res. 2007; 67:2685-2692. PubMed Duensing A, Tseng M, Liu Y, Bartoli K, Spardy N, Teng X, Duensing S. RNA polymerase II transcriptional activity regulates centriole overduplication. Oncogene 2007; 26:215-223. PubMed 2006 Duensing A, Ghanem L, Steinman RA, Liu Y, Duensing S. p21(Waf1/Cip1) deficiency stimulates centriole overduplication. Cell Cycle 2006; 5:2899-2902. PubMed Rubin BP, Duensing A. Mechanisms of resistance to small molecule kinase inhibition in the treatment of solid tumors. Lab. Invest. 2006; 86-981-986. PubMed Duensing A, Teng X, Liu Y, Tseng M, Spardy N, Duensing S. A role of the mitotic spindle checkpoint in the cellular response to DNA replication stress. J Cell. Biochem. 2006; 99:759-769. PubMed Duensing A, Liu Y, Tseng M, Malumbres M, Barbacid M, Duensing S. Cyclin-dependent kinase 2 is dispensable for normal centrosome duplication but required for oncogene-induced centrosome overduplication. Oncogene 2006; 25:2943-2949 . PubMed Munger K, Hayakawa H, Nguyen CL, Melquiot NV, Duensing A, Duensing S. Viral carcinogenesis and genomic instability. EXS 2006; 96:179-199. PubMed 2005 Duensing S. A tentative classification of centrosome abnormalities in cancer. Cell Biol. Int. 2005; 29:352-359. PubMed Duensing A, Duensing S. Guilt by association? p53 and the development of aneuploidy in cancer. Biochem. Biophys. Res. Comm. 2005; 331:694-700. PubMed Li FP, Fletcher JA, Heinrich MC, Garber JE, Sallan SE, Curiel-Lewandrowski C, Duensing A, van de Rijn M, Schnipper LE, Demetri GD. Familial gastrointestinal stromal tumor syndrome: phenotypic and molecular features in a kindred. J. Clin. Oncol. 2005; 23:2735-2743. PubMed Guarguaglini G, Duncan PI, Stierhof YD, Holmstrom T, Duensing S, Nigg EA. The FHA-domain protein Cep170 interacts with Plk1 and serves as a marker for mature centrioles. Mol. Biol. Cell 2005; 16:1095-1107. PubMed 2004 Duensing S, Duensing A, Lee DC, Edwards KM, Piboonniyom S, Manuel E, Skaltsounis l, Meijer L, Münger K. The cyclin-dependent kinase inhibitor indirubin-3’-oxime selectively inhibits human papillomavirus type 16 E7-induced numerical centrosome anomalies. Oncogene 2004; 23:8206-8215. PubMed Duensing A, Joseph NE, Medeiros F, Smith F, Hornick JL, Heinrich MC, Corless CL, Demetri GD, Fletcher CDM, Fletcher JA. Protein Kinase C theta (PKCθ) expression and constitutive activation in gastrointestinal stromal tumors (GISTs). Cancer Res. 2004; 64:5127-5131. PubMed Medeiros F, Corless CL, Duensing A, Hornick JL, Oliveira AM, Heinrich MC, Fletcher JA, Fletcher CDM. KIT-negative gastrointestinal stromal tumors: Proof of concept and therapeutic implications. Am. J. Surg. Pathol. 2004; 28:889-894. PubMed Duensing A, Medeiros F, McConarty B, Joseph NE, Panigrahy D, Singer S, Demetri GD, Fletcher CDM, Fletcher JA. Mechanisms of oncogenic KIT signal transduction in primary gastrointestinal stromal tumors (GISTs). Oncogene 2004; 23:3999-4006. PubMed Hasskarl J*, Duensing S*, Manuel E, Münger. The helix-loop-helix Id1 localizes to centrosomes and rapidly induces abnormal centrosome numbers. (*co-first authors). Oncogene 2004; 23:1930-1938. PubMed Duensing A, Heinrich MC, Fletcher CDM, Fletcher JA. Biology of gastrointestinal stromal tumors: KIT mutations and beyond. Cancer Invest. 2004; 22:106-116. PubMed Duensing S, Münger K. Mechanisms of genomic instability in human cancer: insights from studies with human papillomavirus oncoproteins. Int. J. Cancer 2004; 109:157-162. PubMed Münger K, Duensing S. Human papillomavirus infection and centrosome anomalies in cervical cancer. In: Nigg EA (ed.) “Centrosomes in development and disease” Wiley VCH. Duensing A. Zellbiologische Bedeutung von KIT in gastrointestinalen Stromatumoren (GISTs). Dt. Ärztebl. 2004; 101:A655-656. 2003 Balsitis SJ, Sage J, Duensing S, Münger K, Jacks T, Lambert PF. Recapitulation of the effects of HPV-16 E7 oncogene on mouse epithelium by somatic Rb deletion and detection of pRb-independent effects of E7 in vivo. Mol. Cell. Biol. 2003; 23:9094-9103. PubMed Heinrich MC, Corless CL, Duensing A, McGreevey L, Chen CJ, Joseph N, Singer S, Griffith DJ, Haley A, Town A, Demetri GD, Fletcher CD, Fletcher JA. PDGFRA activating mutations in gastrointestinal stromal tumors. Science 2003: 31:708-710. PubMed Duensing S, Münger K. Human papillomavirus type 16 E7 oncoprotein can induce abnormal centrosome duplication through a mechanism independent of inactivation of retinoblastoma protein family members. J. Virol. 2003; 77:12331-12335. PubMed Duensing S, Lee BH, Dal Cin P, Münger K. Excessive centrosome abnormalities without ongoing numerical chromosome instability in a Burkitt's lymphoma. Mol. Cancer 2003; 2:30. PubMed Riley RR, Duensing S, Brake T, Münger K, Lambert PF, Arbeit JM. Dissection of human papillomavirus E6 and E7 function in transgenic mouse models of cervical carcinogenesis. Cancer Res. 2003; 63:4862-4871. PubMed Genther SM, Sterling S, Duensing S, Münger K, Sattler C, Lambert PF. Quantitative role of the human papillomavirus type 16 E5 gene during the productive stage of the viral life cycle. J. Virol. 2003; 77:2832-2842. PubMed Piboonniyom S, Duensing S, Swilling NW, Hasskarl J, Hinds PW, Münger K. Abrogation of the retinoblastoma tumor suppressor checkpoint during keratinocyte immortalization is not sufficient for induction of centrosome-mediated genomic instability. Cancer Res. 2003; 63:476-483. PubMed Duensing S, Münger K. Centrosomes, genomic instability, and cervical carcinogenesis. Crit. Rev. Eukaryot. Gene Expr. 2003; 13:9-23. PubMed Duensing S, Münger K. Centrosome abnormalities and genomic instability induced by human papillomavirus oncoproteins. In: Meijer L, Jezequel A, Roberge M (Eds.), Prog. Cell Cycle Res. Vol. 5; pp. 383-391 (2003). PubMed 2002 Duensing S, Münger K. The human papillomavirus type 16 E6 and E7 oncoproteins independently induce numerical and structural chromosome instability. Cancer Res. 2002; 62:7075-7082. PubMed Panigrahy D, Singer S, Shen LQ, Butterfield CE, Freedman DA, Chen EJ, Moses MA, Kilroy S, Duensing S, Fletcher C, Fletcher JA, Hlatky L, Hahnfeldt P, Folkman J, Kaipainen A. PPARg ligands inhibit primary tumor growth and metastasis by inhibiting angiogenesis. J. Clin. Invest. 2002; 110:923-932. PubMed Duensing S, Münger K. Human papillomaviruses and centrosome duplication errors: modeling the origins of genomic instability. Oncogene 2002; 21:6241-6248. PubMed 2001 Rubin BP, Singer S, Tsao C, Duensing A, Lux ML, Ruiz R, Hibbard MK, Chen CJ, Xiao S, Tuveson DA, Demetri GD, Fletcher CD, Fletcher JA. KIT activation is a ubiquitous feature of gastrointestinal stromal tumors. Cancer Res. 2001; 61:8118-8121. PubMed Duensing S*, Duensing*, A, Flores ER, Do A, Lambert PF, Münger K. Centrosome abnormalities and genomic instability by episomal expression of human papillomavirus type 16 in raft cultures of human keratinocytes. (*co-first authors) J. Virol. 2001; 75 7712-7716. PubMed Jiang X, Wilford C, Duensing S, Münger K, Jones G, Jones D. Participation of survivin in mitotic and apoptotic activities of normal and tumor-derived cells. J. Cell. Biochem. 2001; 83:342-354. PubMed Keating JT, Cviko A, Riethdorf S, Riethdorf L, Quade BJ, Sun D, Duensing S, Sheets EE, Münger K, Crum CP. Ki-67, cyclin E, p16INK4A are complimentary surrogate biomarkers for HPV-related cervical neoplasia. Am. J. Surg. Path. 2001; 25:884-891. PubMed Duensing S, Duensing A, Crum CP, Münger K. Human papillomavirus type 16 E7 oncoprotein induced abnormal centrosome synthesis is an early event in the evolving malignant phenotype. Cancer Res. 2001; 61:2356-2360. PubMed Münger K, Basile JR, Duensing S, Eichten A, Gonzalez SL, Grace M, Zacny VL. Biological activities and molecular targets of the human papillomavirus E7 oncoprotein. Oncogene 2001; 20:7888-7898. PubMed Duensing S, Münger K. Centrosome abnormalities, genomic instability and carcinogenic progression. Biochim. Biophys. Acta 2001; 1471:M81-M88. PubMed 2000 Duensing S, Lee LY, Duensing A, Basile J, Piboonniyom S, Gonzalez S, Crum CP, Münger K. The human papillomavirus type 16 E6 and E7 oncoproteins cooperate to induce mitotic defects and genomic in |